Basic, Translational, and Clinical Research

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Human Induced Pluripotent Stem Cell–Derived Engineered Heart Tissue as a Sensitive Test System for QT Prolongation and Arrhythmic Triggers
Marc D. Lemoine, Tobias Krause, Jussi T. Koivumäki, Maksymilian Prondzynski, Mirja L. Schulze, Evaldas Girdauskas, Stephan Willems, Arne Hansen, Thomas Eschenhagen and Torsten Christ

Circulation: Arrhythmia and Electrophysiology. 2018;11:e006035, originally published June 20, 2018
https://doi.org/10.1161/CIRCEP.117.006035

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Interaction of Localized Drivers and Disorganized Activation in Persistent Atrial FibrillationReconciling Putative Mechanisms Using Multiple Mapping Techniques
Christopher A.B. Kowalewski, Fatemah Shenasa, Miguel Rodrigo, Paul Clopton, Gabriela Meckler, Mahmood I. Alhusseini, Mark A. Swerdlow, Vijay Joshi, Samir Hossainy, Junaid A.B. Zaman, Tina Baykaner, Albert J. Rogers, Johannes Brachmann, John M. Miller, David E. Krummen, William H. Sauer, Nicholas S. Peters, Paul J. Wang and Sanjiv M. Narayan

Circulation: Arrhythmia and Electrophysiology. 2018;11:e005846, originally published June 8, 2018
https://doi.org/10.1161/CIRCEP.117.005846

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Basal Spontaneous Firing of Rabbit Sinoatrial Node Cells Is Regulated by Dual Activation of PDEs (Phosphodiesterases) 3 and 4
Tatiana M. Vinogradova, Syevda Sirenko, Yevgeniya O. Lukyanenko, Dongmei Yang, Kirill V. Tarasov, Alexey E. Lyashkov, Nevin J. Varghese, Yue Li, Khalid Chakir, Bruce Ziman and Edward G. Lakatta

Circulation: Arrhythmia and Electrophysiology. 2018;11:e005896, originally published June 7, 2018
https://doi.org/10.1161/CIRCEP.117.005896

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Role of 3-Dimensional Architecture of Scar and Surviving Tissue in Ventricular TachycardiaInsights From High-Resolution Ex Vivo Porcine Models
Farhad Pashakhanloo, Daniel A. Herzka, Henry Halperin, Elliot R. McVeigh and Natalia A. Trayanova

Circulation: Arrhythmia and Electrophysiology. 2018;11:e006131, originally published June 7, 2018
https://doi.org/10.1161/CIRCEP.117.006131

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Unraveling the Underlying Arrhythmia Mechanism in Persistent Atrial FibrillationResults From the STARLIGHT Study
Nicholas Child, Richard H. Clayton, Caroline R. Roney, Jacob I. Laughner, Allan Shuros, Petr Neuzil, Jan Petru, Tom Jackson, Bradley Porter, Julian Bostock, Steven A. Niederer, Reza S. Razavi, Christopher A. Rinaldi, Peter Taggart, Matthew J. Wright and Jaswinder Gill

Circulation: Arrhythmia and Electrophysiology. 2018;11:e005897, originally published June 1, 2018
https://doi.org/10.1161/CIRCEP.117.005897

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Circulating MicroRNA-21 Correlates With Left Atrial Low-Voltage Areas and Is Associated With Procedure Outcome in Patients Undergoing Atrial Fibrillation Ablation
Qifeng Zhou, Carole Maleck, Saskia N.I. von Ungern-Sternberg, Balram Neupane, David Heinzmann, Jonathan Marquardt, Martin Duckheim, Christian Scheckenbach, Fabian Stimpfle, Meinrad Gawaz, Jürgen Schreieck, Peter Seizer and Michael Gramlich

Circulation: Arrhythmia and Electrophysiology. 2018;11:e006242, originally published May 30, 2018
https://doi.org/10.1161/CIRCEP.118.006242

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Transient Outward K⁺ Current (I_to) Underlies the Right Ventricular Initiation of Polymorphic Ventricular Tachycardia in a Transgenic Rabbit Model of Long-QT Syndrome Type 1
Bum-Rak Choi, Weiyan Li, Dmitry Terentyev, Anatoli Y. Kabakov, Mingwang Zhong, Colin M. Rees, Radmila Terentyeva, Tae Yun Kim, Zhilin Qu, Xuwen Peng, Alain Karma and Gideon Koren

Circulation: Arrhythmia and Electrophysiology. 2018;11:e005414, originally published May 16, 2018
https://doi.org/10.1161/CIRCEP.117.005414

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Functional Invalidation of Putative Sudden Infant Death Syndrome–Associated Variants in the KCNH2-Encoded Kv11.1 Channel
Jennifer L. Smith, David J. Tester, Allison R. Hall, Don E. Burgess, Chun-Chun Hsu, Samy Claude Elayi, Corey L. Anderson, Craig T. January, Jonathan Z. Luo, Dustin N. Hartzel, Uyenlinh L. Mirshahi, Michael F. Murray, Tooraj Mirshahi, Michael J. Ackerman and Brian P. Delisle

Circulation: Arrhythmia and Electrophysiology. 2018;11:e005859, originally published May 11, 2018
https://doi.org/10.1161/CIRCEP.117.005859

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Minimally Invasive Delivery of Hydrogel-Encapsulated Amiodarone to the Epicardium Reduces Atrial Fibrillation
Jose R. Garcia, Peter F. Campbell, Gautam Kumar, Jonathan J. Langberg, Liliana Cesar, Juline N. Deppen, Eric Y. Shin, Neal K. Bhatia, Lanfang Wang, Kai Xu, Frank Schneider, Brian Robinson, Andrés J. García and Rebecca D. Levit

Circulation: Arrhythmia and Electrophysiology. 2018;11:e006408, originally published May 10, 2018
https://doi.org/10.1161/CIRCEP.118.006408

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Interleukin 10 Treatment Ameliorates High-Fat Diet–Induced Inflammatory Atrial Remodeling and Fibrillation
Hidekazu Kondo, Ichitaro Abe, Koro Gotoh, Akira Fukui, Hiroki Takanari, Yumi Ishii, Yuki Ikebe, Shintaro Kira, Takahiro Oniki, Shotaro Saito, Kohei Aoki, Tomomi Tanino, Kazuki Mitarai, Kyoko Kawano, Miho Miyoshi, Mami Fujinami, Seiichiro Yoshimura, Reika Ayabe, Norihiro Okada, Yasuko Nagano, Hidefumi Akioka, Tetsuji Shinohara, Kumiko Akiyoshi, Takayuki Masaki, Yasushi Teshima, Kunio Yufu, Mikiko Nakagawa and Naohiko Takahashi

Circulation: Arrhythmia and Electrophysiology. 2018;11:e006040, originally published May 10, 2018
https://doi.org/10.1161/CIRCEP.117.006040

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